Endocrine Abstracts

Understanding the molecular factors that regulate human muscle mass is acquiring increasing scientific interest. Hitherto, known (+ve) endocrine regulators of lean body mass included the GH-IGF-1 system, anabolic steroids, and (−ve) myostatin. In order to elucidate this process further, we have investigated a clinical case at a genetic and phenotypic level. A 46-year-old man with idiopathic muscle hypertrophy requiring multiple therapeutic fasciotomies underwent clinical...

Objective: Motilin is a proximal small intestinal hormone with roles in gastrointestinal motility, gallbladder emptying and hunger initiation. The molecular mechanisms underlying motilin release in response to fats, bile and duodenal acidification are poorly understood, in part due a lack of suitable cellular and rodent models. We therefore generated a novel human intestinal organoid model with fluorescently labelled motilin-expressing M-cells, which we used to establish the k...